Type IVB pilus operon promoter controlling expression of the severe acute respiratory syndrome-associated coronavirus nucleocapsid gene in Salmonella enterica Serovar Typhi elicits full immune response by intranasal vaccination.
Identifieur interne : 003560 ( Main/Exploration ); précédent : 003559; suivant : 003561Type IVB pilus operon promoter controlling expression of the severe acute respiratory syndrome-associated coronavirus nucleocapsid gene in Salmonella enterica Serovar Typhi elicits full immune response by intranasal vaccination.
Auteurs : Fengling Luo [République populaire de Chine] ; Yong Feng ; Min Liu ; Pingfei Li ; Qin Pan ; Victor Tunje Jeza ; Bing Xia ; Jianguo Wu ; Xiao-Lian ZhangSource :
- Clinical and vaccine immunology : CVI [ 1556-6811 ] ; 2007.
Descripteurs français
- KwdFr :
- Administration par voie nasale, Animaux, Anticorps antiviraux (sang), Femelle, Humains, Immunité muqueuse, Lymphocytes T cytotoxiques (immunologie), Opéron, Protéines bactériennes (génétique), Protéines bactériennes (immunologie), Protéines bactériennes (métabolisme), Protéines nucléocapside (génétique), Protéines nucléocapside (immunologie), Protéines nucléocapside (métabolisme), Recombinaison génétique, Régions promotrices (génétique), Régulation de l'expression des gènes viraux, Salmonella typhi (génétique), Salmonella typhi (immunologie), Salmonella typhi (métabolisme), Souris, Souris de lignée BALB C, Vaccination, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Vecteurs génétiques, Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- administration et posologie : Vaccins antiviraux.
- génétique : Protéines bactériennes, Protéines nucléocapside, Salmonella typhi, Vaccins antiviraux, Virus du SRAS.
- immunologie : Lymphocytes T cytotoxiques, Protéines bactériennes, Protéines nucléocapside, Salmonella typhi, Vaccins antiviraux, Virus du SRAS.
- métabolisme : Protéines bactériennes, Protéines nucléocapside, Salmonella typhi.
- sang : Anticorps antiviraux.
- Administration par voie nasale, Animaux, Femelle, Humains, Immunité muqueuse, Opéron, Recombinaison génétique, Régions promotrices (génétique), Régulation de l'expression des gènes viraux, Souris, Souris de lignée BALB C, Vaccination, Vecteurs génétiques.
English descriptors
- KwdEn :
- Administration, Intranasal, Animals, Antibodies, Viral (blood), Bacterial Proteins (genetics), Bacterial Proteins (immunology), Bacterial Proteins (metabolism), Female, Gene Expression Regulation, Viral, Genetic Vectors, Humans, Immunity, Mucosal, Mice, Mice, Inbred BALB C, Nucleocapsid Proteins (genetics), Nucleocapsid Proteins (immunology), Nucleocapsid Proteins (metabolism), Operon, Promoter Regions, Genetic, Recombination, Genetic, SARS Virus (genetics), SARS Virus (immunology), Salmonella typhi (genetics), Salmonella typhi (immunology), Salmonella typhi (metabolism), T-Lymphocytes, Cytotoxic (immunology), Vaccination, Viral Vaccines (administration & dosage), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Viral Vaccines.
- chemical , blood : Antibodies, Viral.
- chemical , genetics : Bacterial Proteins, Nucleocapsid Proteins, Viral Vaccines.
- chemical , immunology : Bacterial Proteins, Nucleocapsid Proteins, Viral Vaccines.
- chemical , metabolism : Bacterial Proteins, Nucleocapsid Proteins.
- genetics : SARS Virus, Salmonella typhi.
- immunology : SARS Virus, Salmonella typhi, T-Lymphocytes, Cytotoxic.
- metabolism : Salmonella typhi.
- Administration, Intranasal, Animals, Female, Gene Expression Regulation, Viral, Genetic Vectors, Humans, Immunity, Mucosal, Mice, Mice, Inbred BALB C, Operon, Promoter Regions, Genetic, Recombination, Genetic, Vaccination.
Abstract
Attenuated Salmonella enterica serovar Typhi strains have been considered to be attractive as potential live oral delivery vector vaccines because of their ability to elicit the full array of immune responses in humans. In this study, we constructed an attenuated S. enterica serovar Typhi strain stably expressing conserved nucleocapsid (N) protein of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) by integrating the N gene into the pilV gene, which was under the control of the type IVB pilus operon promoter in S. enterica serovar Typhi. BALB/c mice were immunized with this recombinant strain through different routes: intranasally, orogastrically, intraperitoneally, and intravenously. Results showed that the intranasal route caused the highest production of specific immunoglobulin G (IgG), IgG2a, and secretory IgA, where IgG2a was imprinted as a Th1 cell bias. Moreover, this recombinant live vaccine induced significantly high levels of specific cytotoxic T-lymphocyte activities and increased gamma interferon-producing T cells compared with the parental strain. Our work provides insights into how the type IVB pilus operon promoter controlling SARS-CoV N gene expression in Salmonella might be attractive for a live-vector vaccine against SRAS-CoV infection, for it could induce mucosal, humoral, and cellular immune responses. Our work also indicates that the type IVB pilus operon promoter controlling foreign gene expression in Salmonella can elicit full immune responses by intranasal vaccination.
DOI: 10.1128/CVI.00076-07
PubMed: 17596427
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001D78
- to stream PubMed, to step Curation: 001D78
- to stream PubMed, to step Checkpoint: 001C43
- to stream Ncbi, to step Merge: 001A06
- to stream Ncbi, to step Curation: 001A06
- to stream Ncbi, to step Checkpoint: 001A06
- to stream Main, to step Merge: 003668
- to stream Main, to step Curation: 003560
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Type IVB pilus operon promoter controlling expression of the severe acute respiratory syndrome-associated coronavirus nucleocapsid gene in Salmonella enterica Serovar Typhi elicits full immune response by intranasal vaccination.</title>
<author><name sortKey="Luo, Fengling" sort="Luo, Fengling" uniqKey="Luo F" first="Fengling" last="Luo">Fengling Luo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hubei Province Key Laboratory of Allergy and Immune-Related Diseases, The State Key Laboratory of Virology, Wuhan University School of Medicine, Wuhan 430071, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Immunology, Hubei Province Key Laboratory of Allergy and Immune-Related Diseases, The State Key Laboratory of Virology, Wuhan University School of Medicine, Wuhan 430071</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feng, Yong" sort="Feng, Yong" uniqKey="Feng Y" first="Yong" last="Feng">Yong Feng</name>
</author>
<author><name sortKey="Liu, Min" sort="Liu, Min" uniqKey="Liu M" first="Min" last="Liu">Min Liu</name>
</author>
<author><name sortKey="Li, Pingfei" sort="Li, Pingfei" uniqKey="Li P" first="Pingfei" last="Li">Pingfei Li</name>
</author>
<author><name sortKey="Pan, Qin" sort="Pan, Qin" uniqKey="Pan Q" first="Qin" last="Pan">Qin Pan</name>
</author>
<author><name sortKey="Jeza, Victor Tunje" sort="Jeza, Victor Tunje" uniqKey="Jeza V" first="Victor Tunje" last="Jeza">Victor Tunje Jeza</name>
</author>
<author><name sortKey="Xia, Bing" sort="Xia, Bing" uniqKey="Xia B" first="Bing" last="Xia">Bing Xia</name>
</author>
<author><name sortKey="Wu, Jianguo" sort="Wu, Jianguo" uniqKey="Wu J" first="Jianguo" last="Wu">Jianguo Wu</name>
</author>
<author><name sortKey="Zhang, Xiao Lian" sort="Zhang, Xiao Lian" uniqKey="Zhang X" first="Xiao-Lian" last="Zhang">Xiao-Lian Zhang</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="RBID">pubmed:17596427</idno>
<idno type="pmid">17596427</idno>
<idno type="doi">10.1128/CVI.00076-07</idno>
<idno type="wicri:Area/PubMed/Corpus">001D78</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D78</idno>
<idno type="wicri:Area/PubMed/Curation">001D78</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001D78</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001C43</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001C43</idno>
<idno type="wicri:Area/Ncbi/Merge">001A06</idno>
<idno type="wicri:Area/Ncbi/Curation">001A06</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001A06</idno>
<idno type="wicri:doubleKey">1556-6811:2007:Luo F:type:ivb:pilus</idno>
<idno type="wicri:Area/Main/Merge">003668</idno>
<idno type="wicri:Area/Main/Curation">003560</idno>
<idno type="wicri:Area/Main/Exploration">003560</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Type IVB pilus operon promoter controlling expression of the severe acute respiratory syndrome-associated coronavirus nucleocapsid gene in Salmonella enterica Serovar Typhi elicits full immune response by intranasal vaccination.</title>
<author><name sortKey="Luo, Fengling" sort="Luo, Fengling" uniqKey="Luo F" first="Fengling" last="Luo">Fengling Luo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hubei Province Key Laboratory of Allergy and Immune-Related Diseases, The State Key Laboratory of Virology, Wuhan University School of Medicine, Wuhan 430071, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Immunology, Hubei Province Key Laboratory of Allergy and Immune-Related Diseases, The State Key Laboratory of Virology, Wuhan University School of Medicine, Wuhan 430071</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feng, Yong" sort="Feng, Yong" uniqKey="Feng Y" first="Yong" last="Feng">Yong Feng</name>
</author>
<author><name sortKey="Liu, Min" sort="Liu, Min" uniqKey="Liu M" first="Min" last="Liu">Min Liu</name>
</author>
<author><name sortKey="Li, Pingfei" sort="Li, Pingfei" uniqKey="Li P" first="Pingfei" last="Li">Pingfei Li</name>
</author>
<author><name sortKey="Pan, Qin" sort="Pan, Qin" uniqKey="Pan Q" first="Qin" last="Pan">Qin Pan</name>
</author>
<author><name sortKey="Jeza, Victor Tunje" sort="Jeza, Victor Tunje" uniqKey="Jeza V" first="Victor Tunje" last="Jeza">Victor Tunje Jeza</name>
</author>
<author><name sortKey="Xia, Bing" sort="Xia, Bing" uniqKey="Xia B" first="Bing" last="Xia">Bing Xia</name>
</author>
<author><name sortKey="Wu, Jianguo" sort="Wu, Jianguo" uniqKey="Wu J" first="Jianguo" last="Wu">Jianguo Wu</name>
</author>
<author><name sortKey="Zhang, Xiao Lian" sort="Zhang, Xiao Lian" uniqKey="Zhang X" first="Xiao-Lian" last="Zhang">Xiao-Lian Zhang</name>
</author>
</analytic>
<series><title level="j">Clinical and vaccine immunology : CVI</title>
<idno type="ISSN">1556-6811</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intranasal</term>
<term>Animals</term>
<term>Antibodies, Viral (blood)</term>
<term>Bacterial Proteins (genetics)</term>
<term>Bacterial Proteins (immunology)</term>
<term>Bacterial Proteins (metabolism)</term>
<term>Female</term>
<term>Gene Expression Regulation, Viral</term>
<term>Genetic Vectors</term>
<term>Humans</term>
<term>Immunity, Mucosal</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Nucleocapsid Proteins (genetics)</term>
<term>Nucleocapsid Proteins (immunology)</term>
<term>Nucleocapsid Proteins (metabolism)</term>
<term>Operon</term>
<term>Promoter Regions, Genetic</term>
<term>Recombination, Genetic</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (immunology)</term>
<term>Salmonella typhi (genetics)</term>
<term>Salmonella typhi (immunology)</term>
<term>Salmonella typhi (metabolism)</term>
<term>T-Lymphocytes, Cytotoxic (immunology)</term>
<term>Vaccination</term>
<term>Viral Vaccines (administration & dosage)</term>
<term>Viral Vaccines (genetics)</term>
<term>Viral Vaccines (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie nasale</term>
<term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunité muqueuse</term>
<term>Lymphocytes T cytotoxiques (immunologie)</term>
<term>Opéron</term>
<term>Protéines bactériennes (génétique)</term>
<term>Protéines bactériennes (immunologie)</term>
<term>Protéines bactériennes (métabolisme)</term>
<term>Protéines nucléocapside (génétique)</term>
<term>Protéines nucléocapside (immunologie)</term>
<term>Protéines nucléocapside (métabolisme)</term>
<term>Recombinaison génétique</term>
<term>Régions promotrices (génétique)</term>
<term>Régulation de l'expression des gènes viraux</term>
<term>Salmonella typhi (génétique)</term>
<term>Salmonella typhi (immunologie)</term>
<term>Salmonella typhi (métabolisme)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Vaccination</term>
<term>Vaccins antiviraux (administration et posologie)</term>
<term>Vaccins antiviraux (génétique)</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Vecteurs génétiques</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term>
<term>Nucleocapsid Proteins</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Bacterial Proteins</term>
<term>Nucleocapsid Proteins</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bacterial Proteins</term>
<term>Nucleocapsid Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term>
<term>Salmonella typhi</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines bactériennes</term>
<term>Protéines nucléocapside</term>
<term>Salmonella typhi</term>
<term>Vaccins antiviraux</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T cytotoxiques</term>
<term>Protéines bactériennes</term>
<term>Protéines nucléocapside</term>
<term>Salmonella typhi</term>
<term>Vaccins antiviraux</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term>
<term>Salmonella typhi</term>
<term>T-Lymphocytes, Cytotoxic</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Salmonella typhi</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines bactériennes</term>
<term>Protéines nucléocapside</term>
<term>Salmonella typhi</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term>
<term>Animals</term>
<term>Female</term>
<term>Gene Expression Regulation, Viral</term>
<term>Genetic Vectors</term>
<term>Humans</term>
<term>Immunity, Mucosal</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Operon</term>
<term>Promoter Regions, Genetic</term>
<term>Recombination, Genetic</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunité muqueuse</term>
<term>Opéron</term>
<term>Recombinaison génétique</term>
<term>Régions promotrices (génétique)</term>
<term>Régulation de l'expression des gènes viraux</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Vaccination</term>
<term>Vecteurs génétiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Attenuated Salmonella enterica serovar Typhi strains have been considered to be attractive as potential live oral delivery vector vaccines because of their ability to elicit the full array of immune responses in humans. In this study, we constructed an attenuated S. enterica serovar Typhi strain stably expressing conserved nucleocapsid (N) protein of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) by integrating the N gene into the pilV gene, which was under the control of the type IVB pilus operon promoter in S. enterica serovar Typhi. BALB/c mice were immunized with this recombinant strain through different routes: intranasally, orogastrically, intraperitoneally, and intravenously. Results showed that the intranasal route caused the highest production of specific immunoglobulin G (IgG), IgG2a, and secretory IgA, where IgG2a was imprinted as a Th1 cell bias. Moreover, this recombinant live vaccine induced significantly high levels of specific cytotoxic T-lymphocyte activities and increased gamma interferon-producing T cells compared with the parental strain. Our work provides insights into how the type IVB pilus operon promoter controlling SARS-CoV N gene expression in Salmonella might be attractive for a live-vector vaccine against SRAS-CoV infection, for it could induce mucosal, humoral, and cellular immune responses. Our work also indicates that the type IVB pilus operon promoter controlling foreign gene expression in Salmonella can elicit full immune responses by intranasal vaccination.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Hubei</li>
</region>
<settlement><li>Wuhan</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Feng, Yong" sort="Feng, Yong" uniqKey="Feng Y" first="Yong" last="Feng">Yong Feng</name>
<name sortKey="Jeza, Victor Tunje" sort="Jeza, Victor Tunje" uniqKey="Jeza V" first="Victor Tunje" last="Jeza">Victor Tunje Jeza</name>
<name sortKey="Li, Pingfei" sort="Li, Pingfei" uniqKey="Li P" first="Pingfei" last="Li">Pingfei Li</name>
<name sortKey="Liu, Min" sort="Liu, Min" uniqKey="Liu M" first="Min" last="Liu">Min Liu</name>
<name sortKey="Pan, Qin" sort="Pan, Qin" uniqKey="Pan Q" first="Qin" last="Pan">Qin Pan</name>
<name sortKey="Wu, Jianguo" sort="Wu, Jianguo" uniqKey="Wu J" first="Jianguo" last="Wu">Jianguo Wu</name>
<name sortKey="Xia, Bing" sort="Xia, Bing" uniqKey="Xia B" first="Bing" last="Xia">Bing Xia</name>
<name sortKey="Zhang, Xiao Lian" sort="Zhang, Xiao Lian" uniqKey="Zhang X" first="Xiao-Lian" last="Zhang">Xiao-Lian Zhang</name>
</noCountry>
<country name="République populaire de Chine"><region name="Hubei"><name sortKey="Luo, Fengling" sort="Luo, Fengling" uniqKey="Luo F" first="Fengling" last="Luo">Fengling Luo</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003560 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003560 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:17596427 |texte= Type IVB pilus operon promoter controlling expression of the severe acute respiratory syndrome-associated coronavirus nucleocapsid gene in Salmonella enterica Serovar Typhi elicits full immune response by intranasal vaccination. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:17596427" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
This area was generated with Dilib version V0.6.33. |